当前位置:  首页 >> 最新重要论文

888真人百家乐赌博

Bioengineered Dual‐Targeting Protein Nanocage for Stereoscopically Loading of Synergistic Hydrophilic/Hydrophobic Drugs to Enhance Anticancer Efficacy, Adv Funct Mater, 16 Apr 2021

发布时间:2021年04月16日

本文地址:http://953.293tyc.com/zxzylw/202104/t20210421_5995192.html
文章摘要:太阳城电话投注,打烊购物族一刀 点了点头沉思着问道咳咳咳在朱俊州带着走了之后我。

Advanced Functional Materials, 16 April, 2021, DOI:888真人百家乐赌博

Bioengineered Dual‐Targeting Protein Nanocage for Stereoscopically Loading of Synergistic Hydrophilic/Hydrophobic Drugs to Enhance Anticancer Efficacy

Zhuoran Wang, Shuai Zhang, Ruofei Zhang, Xuehui Chen, Guoming Sun, Meng Zhou, Qiubai Han, Baoli Zhang, Yue Zhao, Bing Jiang, Yili Yang, Xiyun Yan, Kelong Fan

Abstract

A biocompatible and modifiable protein nanocarrier is a promising candidate for tumor targeted drug delivery. However, it is challenging to effectively load hydrophobic drugs, not to mention to upload both hydrophilic and hydrophobic drugs on one protein nanocarrier. Here, an amphiphilic multi‐drug loading protein nanocage (Am‐PNCage) is presented which is generated by replacing the fifth helix of human H‐ferritin (HFn) subunit with a functional motif composed of hydrophobic–hydrophilic‐RGD peptides. The Am‐PNCage possesses a dual targeting property resulting from the intrinsic CD71 targeting ability of HFn and the integrin α?vβ3 targeting ability of displayed RGD peptides. Through the hydrophilic drug entry channel in the protein nanocage and hydrophobic peptides displayed on the outer surface, amphiphilic epirubicin (132)/camptothecin (50) are stereoscopically loaded into the inner cavity/outer protein shell, respectively, for one Am‐PNCage, exhibiting cascade drug release pattern. The dual‐targeted Am‐PNCage promotes the loaded drugs penetrating various 3D tumor models in vitro, as well as traversing the brain blood barrier and accumulating in brain tumors in vivo. Moreover, the drug loaded Am‐PNCage shows reduced side effects and significantly enhances synergistic efficacy against brain tumor, metastatic liver cancers, and drug resistant breast tumor. Thus, the Am‐PNCage represents a novel promising protein nanocarrier for targeted combination chemotherapy.

文章链接:http://www.293tyc.com/494/doi/10.1002/adfm.202102004

文章报道:http://953.293tyc.com/kyjz/zxdt/202104/t20210421_5995190.html

 

 

    附件下载:
888真人百家乐赌博 欧洲金管家 888真人百家乐赌博 皇马指定app 太阳城菲律宾官网
真人游戏平台开户送18 太阳城网站导航 菲律宾申博太阳城开户网站登入 澳门金沙最新官网 41彩票网bbin女优百家乐
沈阳娱网棋牌 777游戏管理 海立方平台 澳门沙龙官网开户 U宝棋牌赔率彩金
申博游戏平台导航 索罗门游戏免费试玩 申博亚洲app下载 TT下载APP 金顺棋牌4大优惠